Promethazine is undoubtedly an H1 receptor blocking agent. Together with its antihistaminic motion, it provides clinically handy sedative and antiemetic effects.
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Codeine: In people acquiring MAO inhibitors, an Original compact exam dose is highly recommended to permit observation of any abnormal narcotic results or MAOI interaction.
The next significant adverse reactions are described, or described in increased detail, in other sections:
Promethazine is well absorbed with the gastrointestinal tract. Medical effects are obvious in twenty minutes soon after oral administration and usually previous four to six several hours, Though They might persist providing 12 hrs.
Promethazine Carcinogenicity scientific tests were done with promethazine hydrochloride. Two-yr scientific tests in F344/N rats and B6C3F1 mice were being done to evaluate the carcinogenic opportunity of promethazine hydrochloride. No evidence of tumorigenicity was noticed in male and feminine rats at promethazine hydrochloride oral doses approximately 33 mg/kg/working day for five days/week (around such as ten instances the MRHD on a mg/m2 foundation).
Sedation This product relieves apprehension and induces a tranquil slumber from which the affected person can be easily aroused.
It truly is strongly encouraged that an precise measuring unit be utilized. A pharmacist can provide an suitable gadget and can offer Guidelines for measuring the right dose.
Promethazine HCl Oral Resolution may well decreased seizure threshold. It should be utilized with warning in people with seizure Ailments or in individuals who will be working with concomitant drugs, including narcotics or local anesthetics, which can also influence seizure threshold.
It truly is soluble in water and freely soluble in Alcoholic beverages. It's a molecular weight of 320.88, a molecular system of C17H20N2S•HCl, and the next structural components:
Extreme drowsiness and diminished psychological alertness. Promethazine HCl Oral Option may possibly induce drowsiness which can impair your ability to journey a motorbike, push a car, or work machinery.
Neuroleptic malignant syndrome (NMS) which can cause read more Loss of life. Let you know Health care service provider without delay When you've got any of the subsequent indicators of NMS:
Promethazine is a phenothiazine derivative which differs structurally through the antipsychotic phenothiazines from the existence of the branched facet chain and no ring substitution.
Promethazine HCl Oral Solution needs to be used cautiously in individuals with heart problems or with impairment of liver function.